Integrin alpha6beta1

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

Also Known As:

CD49f-CD29; Integrin alpha(6)beta(1); Integrin alpha6Abeta1; Integrin alpha6Bbeta1; Platelet Glycoprotein I'c-IIa; VLA-6; alpha 6 beta 1 Integrin; alpha6beta1 Integrin; CD49f CD29; Glycoprotein I'c-IIa, Platelet; I'c-IIa, Platelet Glycoprotein; Integrin, alpha6beta1; Platelet Glycoprotein I'c IIa; VLA 6; alpha6Abeta1, Integrin; alpha6Bbeta1, Integrin; alpha6beta1, Integrin

Carbohydrates: 22516
- Glycoconjugates: 1370
  - Glycoproteins: 25180
    - Membrane Glycoproteins: 2277
      - Platelet Membrane Glycoproteins: 1215
        Integrin alpha6beta1: 83
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Glycoproteins: 25180
    - Membrane Glycoproteins: 2277
      - Platelet Membrane Glycoproteins: 1215
        Integrin alpha6beta1: 83
  - Membrane Proteins: 10262
    - Membrane Glycoproteins: 2277
      - Platelet Membrane Glycoproteins: 1215
        Integrin alpha6beta1: 83
    - Cell Surface Receptors: 2156
      - Immunologic Receptors: 10
        Integrins: 14566
        Very Late Antigen Receptors: 8
        Integrin alpha6beta1: 83
        Platelet Membrane Glycoproteins: 1215
        Integrin alpha6beta1: 83
        Laminin Receptors: 519
        Integrin alpha6beta1: 83

A J Docherty Selected Research

A J Docherty Research Topics

Disease

Drug/Important Bio-Agent (IBA)